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病毒与宿主相互作用；抗病毒天然免疫与病毒免疫逃逸。

获批代表性科研项目：

1) 国家重点研发项目，2024YFA1803100，病原体感染与宿主代谢系统互作及靶向干预研究，2024.12至2029.11，2200万，在研，项目骨干

2) 国家高层次人才特殊支持计划青年拔尖人才项目，2022.10至2025.10，180万，在研，主持

3) 国家自然科学基金委，面上项目，32470929，2025.01至2028.12，50万，在研，主持

4) 国家自然科学基金委，面上项目，32270757，PWWP3A调控抗病毒天然免疫反应的机制研究，2023.01至2026.12，54万，在研，主持

5) 湖北省青年拔尖人才项目，2021-12至2024-12，60万，主持

6) 国家自然科学基金委，面上项目，32070773，端锚聚合酶TNKS通过泛素连接酶RNF146调控抗病毒天然免疫的机制研究，2021.01至2024.12，58万，结题，主持

7) 国家自然科学基金委，面上项目，31870870，去泛素化酶USP19在炎症反应中的功能及作用机制研究，2019.01至2022.12，58万，结题，主持

8) 湖北省自然科学基金—群体创新项目（项目骨干）2项，2021年，2023年

9) 国家自然科学基金委，青年项目，31400747，ECSIT在VISA信号复合物组装及细胞抗病毒反应中的作用机制研究，2015.01至2017.12，26万，结题，主持

10) 国家高技术研究发展计划（863）青年科学家专题：基于昆虫病毒衣壳的新型抗原展示系统的建立与优化。项目骨干，项目编号：2015AA020939，2015.01至2017.12

代表性论文（#第一作者，*通讯作者）：

1) Shi Mengling#, Wang Cong#, Chen Zhen#, Zhou Yidan, Yue Liang, Liu Yu, Guo Tiannan, Shang Jun, Xu Haotian, Zhang Yu, Luo Mengcheng* and Lei Caoqi*. PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses. Nature Communications, 2025, doi.org/10.1038/s41467-025-59421-x  

2) Fang Han#, Shi Mengling#,Wang Cong#, Zhang Saiting#, Kong Na, Ji Mengyao, Wang Yan, Zhou Yidan, Zhu Qiyun, Zhang Yu, Du Shishen, Xu Shuai*, Lei Caoqi *, PCSK9 potentiates innate immune response to RNA viruses by preventing AIP4-mediated polyubiquitination and degradation of VISA/MAVS，PNAS, 2025, doi.org/10.1073/pnas.2412206122.  

3) Xu Yanran#, Shi Mengling#, Zhang Yu#, Kong Na, Wang Cong, Xiao Yifeng, Du Shishen, Zhu Qiyun, Lei Caoqi*. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation. PNAS, 2022, doi.org/10.1073/pnas.2122805119.  

4) Zeng Yan#, Xu Shuai#, Wei Yanli, Zhang Xuefeng, Wang Qian, Jia Yane, Wang Wanbing, Han Lu, Chen Zhaoshan, Wang Zhengxiang, Zhang Bo, Chen Hualan, Lei Caoqi*, Zhu Qiyun*. The PB1 Protein of Influenza A Virus Inhibits the Innate Immune Response by Targeting MAVS for NBR1-Mediated Selective Autophagic Degradation. PLoS Pathogens, 2021. doi.org/10.1371/journal.ppat.1009300.

5) Xu Yanran, Lei Caoqi*. TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses. Frontiers in Immunology, 2021. doi.org/10.3389/fimmu.2020.608976. 

6). Wei Yanli#, Zeng Yan#, Zhang Xuegang, Xu Shuai, Wang Zhengxiang, Du Yingying, Zhang Bo, Lei Caoqi*, Zhu Qiyun*. The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. Journal of Virology, 2020, 23;94(24):e01640-20.  

7) Zhong Xuan, Feng Lu, Xu Wenhua, Wuxin, Ding Yidi, Zhou Yan, Lei Caoqi*, Shu Hongbing*. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating its ligand binding. Cellular & Molecular Immunology, 2020, 17(7):741-752. (SCI一区Top)

8) Lei Caoqi#*, Wu Xin#, Zhong Xuan, Jiang Lu, Zhong Bo, Shu Hongbing*. USP19 inhibits TNFa- and IL-1b-triggered NF-kB activation by deubiquitinating TAK1. Journal of Immunology, 2019, 203(1):259-268.

9) Chen Zhen#, Lei Caoqi#, Wang Chao, Li Nan, Mrinal Srivastava, Tang Mengfan, Zhang Huimin, Choi Jongmin, Jung Sungyun, Qin Jun, Chen Junjie*. Global Phosphoproteomic Analysis Reveals ARMC10 as an AMPK Substrate that Regulates Mitochondrial Dynamics. Nature Communications, 2019, 10: 104.  

10) Wang Junyong#, Zeng Yan#, Xu Shuai, Yang Jiayun, Wang Wanbing, Ge Jinying, Yin Lei, Wang Zhengxiang, Han Lu, Cui Xiaole, Zhong Bo, Shu Hongbing, Chen Hualan, Lei Caoqi*, Zhu Qiyun*, A naturally occurring deletion in the effector domain of H5N1 influenza virus nonstructural protein 1 regulates viral fitness and host innate immunity. Journal of Virology, 2018, 92(11): e00149-18.

11) Wang Junyong#, Lei Caoqi*, Ji Yanhong, Zhou Hongbo, Ren Yujie, Peng Qianqian, Zeng Yan, Jia Yane, Ge Jinying, Zhong Bo, Li Yu, Wei Jianzhong, Shu Hongbing, Zhu Qiyun*, Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-beta Signaling Pathways by Targeting VISA. Journal of Immunology, 2016, 197(12):4704-4713.

12) Lei Caoqi, Zhang Yu, Li Mi, Jiang Liqun, Zhong Bo, Kim Yonghao, Shu Hongbing*, ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses. Journal of Innate Immunity, 2015, 7(2):153-164.

13) Lei Caoqi, Zhang Yu, Xia Tian, Jiang Liqun, Zhong Bo, Shu Hongbing*, FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. Journal of Biological Chemistry, 2013, 288(18):12596-12604.

14) Lei Caoqi, Zhong Bo, Zhang Yu, Zhang Jing, Wang Shuai, Shu Hongbing*， Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity, 2010, 33(6):878-889.